As activities in space expand across all orbital regimes, the need for in-space refueling is becoming increasingly evident. This paper presents an OTV-enabled refueling architecture, leveraging high-thrust orbital transfer vehicles (OTVs) and propellant depots to establish a scalable, flexible, and cost-effective space logistics network. A specific use case is explored using Impulse Space’s Helios tugs, which offer fast, high-ΔV maneuvers, this system enables rapid fuel delivery across multiple orbits, making refueling a viable and efficient part of space operations. This approach reduces dependence on pre-staged propellant, lowers mission costs, and enhances operational resilience by ensuring fuel is available where and when it is needed, rather than requiring precise pre-mission planning and rigid fuel allocation strategies.